What is an important difference between the biosynthesis of purine nucleotides and pyrimidine nucleotides?

A. The growing pyrimidine ring is bonded to ribose while the ribose is added later to the purine ring.
B. Purine nucleotides require N10-formylmethyltetrahydrofolate in their biosynthetic pathways.
C. The growing purine ring is bonded to ribose while the ribose is added later to the pyrimidine ring.
D. Proline is the precursor for purine biosynthesis while it is not for pyrimidine biosynthesis.