Answer: Physostigmine is the drug of choice for treating poisoning from atropine and other drugs thatcause muscarinic blockade. Donepezil is used to treat Alzheimer's disease. Edrophonium is usedto distinguish between a myasthenic crisis and a cholinesterase inhibitor overdose. Neostigmine does not cross the blood-brain barrier and would not effectively treat this patient's CNSsymptoms.
